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Inflammation. 2015 Oct;38(5):1769-76. doi: 10.1007/s10753-015-0154-9.

Alpha-Tomatine Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated Macrophages.

Author information

1
Graduate School, Xuzhou Medical College, Xuzhou, 221004, Jiangsu, China.

Abstract

Alpha (α)-tomatine is the major saponin and occurs naturally in tomatoes, which has been confirmed to possess a variety of biological properties including antitumoral, antioxidant, and anti-inflammatory. However, the anti-inflammatory mechanism of α-tomatine is not well understood. This study aims to investigate the anti-inflammatory effects and mechanisms of α-tomatine. Results showed that α-tomatine significantly suppressed the production of pro-inflammatory cytokines in lipopolysaccharide (LPS)-induced macrophages. Moreover, LPS-mediated nuclear translocation of the nuclear factor-kappaB (NF-κB)-p65 and phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 were attenuated after α-tomatine treatment. Still, LPS slightly promoted phosphorylation of Akt, and α-tomatine accelerated the phosphorylation of Akt in macrophages. Our findings indicate that α-tomatine may be a valuable therapeutic agent in the treatment of inflammation-related diseases.

PMID:
25772114
DOI:
10.1007/s10753-015-0154-9
[Indexed for MEDLINE]

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