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Int J Cardiol. 2015 Apr 1;184:692-8. doi: 10.1016/j.ijcard.2015.03.068. Epub 2015 Mar 7.

Relative and absolute risks of all-cause and cause-specific deaths attributable to atrial fibrillation in middle-aged and elderly community dwellers.

Author information

1
Department of Hygiene and Preventive Medicine, Iwate Medical University, Japan. Electronic address: masakio@iwate-med.ac.jp.
2
Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan.
3
Department of Neurosurgery, Iwate Medical University, Morioka, Japan.
4
Department of Urology, Iwate Medical University, Morioka, Japan.
5
Department of Hygiene and Preventive Medicine, Iwate Medical University, Japan.
6
Department of Community Health Sciences, University of Calgary, Canada.
7
Department of Nutritional Sciences, Morioka University, Takizawa, Japan.
8
Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
9
Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan.
10
Department of Health and Physical Education, Faculty of Education, Iwate University, Morioka, Japan.
11
Iwate Health Service Association, Morioka, Japan.
12
The Research Institute of Strategy for Prevention, Tokyo, Japan.

Abstract

BACKGROUND:

The relative and absolute risks of outcomes other than all-cause death (ACD) attributable to atrial fibrillation (AF) stratified age have not been sufficiently investigated.

METHODS:

A prospective study of 23,634 community dwellers aged 40 years or older without organic cardiovascular disease (AF=335, non-AF=23,299) was conducted. Multivariate-adjusted rates, rate ratios (RRs) and excess deaths (EDs) for ACD, cardiovascular death (CVD) and non-cardiovascular death (non-CVD), and sex- and age-adjusted RR and ED in middle-aged (40 to 69) and elderly (70 years or older) for ACD, CVD, non-CVD, sudden cardiac death (SCD), stroke-related death (Str-D), neoplasm-related death (NPD), and infection-related death (IFD) attributable to AF were estimated using Poisson regression.

RESULTS:

Multivariate-adjusted analysis revealed that AF significantly increased the risk of ACD (RR [95% confidence interval]:1.70 [1.23-2.95]) and CVD (3.86 [2.38-6.27]), but not non-CVD. Age-stratified analysis revealed that AF increased the risk of Str-D in middle-aged (14.5 [4.77-44.3]) and elderly individuals (4.92 [1.91-12.7]), SCD in elderly individuals (3.21 [1.37-7.51]), and might increase the risk of IFD in elderly individuals (2.02 [0.80-4.65], p=0.098). The RR of CVD was higher in middle-aged versus elderly individuals (RRs, 6.19 vs. 3.57) but the absolute risk difference was larger in elderly individuals (EDs: 7.6 vs. 3.0 per 1000 person-years).

CONCLUSIONS:

Larger absolute risk differences for ACD and CVD attributable to AF among elderly people indicate that the absolute burden of AF is higher in elderly versus middle-aged people despite the relatively small RR.

KEYWORDS:

Absolute risk difference; Atrial fibrillation; Cardiovascular death; Non-cardiovascular death; Relative risk; Sudden cardiac death

PMID:
25771238
DOI:
10.1016/j.ijcard.2015.03.068
[Indexed for MEDLINE]

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