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Curr Opin Immunol. 2015 Jun;34:83-90. doi: 10.1016/j.coi.2015.02.009. Epub 2015 Mar 11.

Transport and quality control of MHC class I molecules in the early secretory pathway.

Author information

1
Jacobs University Bremen, Germany. Electronic address: sebastian.springer@queens.oxon.org.

Abstract

Folding and peptide binding of major histocompatibility complex (MHC) class I molecules have been thoroughly researched, but the mechanistic connection between these biochemical events and the progress of class I through the early secretory pathway is much less well understood. This review focuses on the question how the partially assembled forms of class I (which lack high-affinity peptide and/or the light chain beta-2 microglobulin) are retained inside the cell. Such investigations offer researchers exciting chances to understand the connections between class I structure, conformational dynamics, peptide binding kinetics and thermodynamics, intracellular transport, and antigen presentation.

PMID:
25771183
DOI:
10.1016/j.coi.2015.02.009
[Indexed for MEDLINE]

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