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Int J Cardiol. 2015 Apr 1;184:617-22. doi: 10.1016/j.ijcard.2015.03.052. Epub 2015 Mar 5.

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies.

Author information

1
Department of Cardiology, General Hospital of Grevena, Greece.
2
Department of Cardiology, University of Ioannina Medical School, Greece. Electronic address: p.korantzopoulos@yahoo.gr.
3
Department of Cardiology, University of Ioannina Medical School, Greece.
4
Cardiology Department, Heraklion University Hospital, Crete, Greece.
5
Tianjin Institute of Cardiology, Second Hospital of Tanjin Medical University, Tianjin, People's Republic of China.
6
Department of Cardiology, Interbalkan Medical Center, Thessaloniki, Greece.

Abstract

Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation (AF) while AF is a strong and independent marker of overall mortality and cardiovascular morbidity in diabetic patients. Autonomic, electrical, electromechanical, and structural remodeling, including oxidative stress, connexin remodeling and glycemic fluctuations seem to be implicated in AF pathophysiology in the setting of DM. The present review highlights the association between DM and AF, provides a comprehensive overview of the responsible pathophysiological mechanisms and briefly discusses potential upstream therapies for DM-related atrial remodeling.

KEYWORDS:

Atrial fibrillation; Atrial remodeling; Diabetes mellitus; Upstream therapies

PMID:
25770841
DOI:
10.1016/j.ijcard.2015.03.052
[Indexed for MEDLINE]

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