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Sleep Med. 2015 Apr;16(4):437-45. doi: 10.1016/j.sleep.2014.11.014. Epub 2015 Feb 14.

Overview of proteomics studies in obstructive sleep apnea.

Author information

1
Serviço de Pneumologia, Centro Hospitalar Lisboa Norte, E.P.E., Lisboa, Portugal; Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
2
Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
3
Serviço de Pneumologia, Centro Hospitalar Lisboa Norte, E.P.E., Lisboa, Portugal.
4
Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, CA, USA; Division of Sleep Medicine Sleep Disorders Research Program Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
5
Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal. Electronic address: deborah.penque@insa.min-saude.pt.

Abstract

Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.

KEYWORDS:

Biomarkers; Lung; Mass spectrometry; Metabolic disorders; Obstructive sleep apnea; Proteomics

PMID:
25770042
PMCID:
PMC4402077
DOI:
10.1016/j.sleep.2014.11.014
[Indexed for MEDLINE]
Free PMC Article

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