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Exp Biol Med (Maywood). 2015 Nov;240(11):1387-95. doi: 10.1177/1535370215576313. Epub 2015 Mar 13.

Parkinson's disease and enhanced inflammatory response.

Author information

1
Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA.
2
Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA bradmorrison@boisestate.edu.

Abstract

Parkinson's disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a loss of midbrain dopaminergic (DA) neurons. However, the molecular cause of DA neuron loss remains elusive. Mounting evidence implicates enhanced inflammatory response in the development and progression of PD pathology. This review examines current research connecting PD and inflammatory response.

KEYWORDS:

Parkinson’s disease; disease models; inflammation; neuroinflammation

PMID:
25769314
PMCID:
PMC4935292
DOI:
10.1177/1535370215576313
[Indexed for MEDLINE]
Free PMC Article

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