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Cell. 2015 Mar 12;160(6):1039-40. doi: 10.1016/j.cell.2015.02.036.

A molecular take on Aesop's The oak and the reeds.

Author information

1
Department of Pathology and Cell Biology, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
2
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA; Howard Hughes Medical Institute, Columbia University, 650 West 168th Street, New York, NY 10032, USA. Electronic address: ecg2108@columbia.edu.

Abstract

Ngo et al. use single-molecule methods to show that DNA can be more readily displaced from one side of a nucleosome relative to the other side. This unexpected mechanical asymmetry may offer a path of least resistance, allowing RNA polymerases to traverse nucleosomes if they approach from the correct direction.

PMID:
25768898
DOI:
10.1016/j.cell.2015.02.036
[Indexed for MEDLINE]
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