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Retina. 2015 Apr;35(4):624-7. doi: 10.1097/IAE.0000000000000589.

MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma.

Author information

1
Departments of *Ophthalmology, †Molecular Medicine, and ‡Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Abstract

PURPOSE:

To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas.

METHODS:

The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation.

RESULTS:

The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases.

CONCLUSION:

Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

PMID:
25768255
DOI:
10.1097/IAE.0000000000000589
[Indexed for MEDLINE]

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