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Iran J Child Neurol. 2015 Winter;9(1):99-102.

Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature.

Author information

1
Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran ; Department of Psychiatry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran ; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Professor of Psychiatry, School of Medicine, Deakin University, Melbourne, Australia ; Professorial Research Fellow, The Florey Institute of Neuroscience and Mental Health, Orygen Research Centre and the Department of Psychiatry, University of Melbourne, Melbourne, Australia.

Abstract

Autism is a disorder of unknown etiology. There are few FDA approved medications for treating autism. Co-occurring autism and epilepsy is common, and glutamate antagonists improve some symptoms of autism. Ceftriaxone, a beta-lactam antibiotic, increases the expression of the glutamate transporter 1 which decreases extracellular glutamate levels. It is hypothesized that modulating astrocyte glutamate transporter expression by ceftriaxone or cefixime might improve some symptoms of autism. This case report of a child with autism and epilepsy suggests a decrease in seizures after taking cefixime.

KEYWORDS:

Antibiotic; Cefixime; Glutamate; Inflammation; Therapy; Transporter

PMID:
25767546
PMCID:
PMC4322506

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