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Onco Targets Ther. 2015 Mar 3;8:539-48. doi: 10.2147/OTT.S75899. eCollection 2015.

The role of miR-29b in cancer: regulation, function, and signaling.

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Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Department of Urology, The Central Hospital of Changsha, Changsha, People's Republic of China.


MicroRNAs (miRNAs) are endogenous small non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. The miRNA-29 family consists of miR-29a, miR-29b, and miR-29c, among which miR-29b is the most highly expressed and is found at two genomic loci. Recently, numerous studies have demonstrated that aberrant expression of miR-29b is common in the majority of human cancers. miR-29b is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain conditions. In this review, we illustrate the role of miR-29b in cancer regulation, function, and signaling. This is the first review highlighting the role of miR-29b in cancer. Our review aims to summarize the effects of miR-29b on cancer activity and its interactions with target genes and signaling pathways, as well as to provide therapeutic implications for overcoming cancer chemoresistance.


biological function; cancer; chemoresistance; miR-29b; oncogene; tumor promoter

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