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Onco Targets Ther. 2015 Mar 3;8:539-48. doi: 10.2147/OTT.S75899. eCollection 2015.

The role of miR-29b in cancer: regulation, function, and signaling.

Author information

1
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
2
Department of Urology, The Central Hospital of Changsha, Changsha, People's Republic of China.

Abstract

MicroRNAs (miRNAs) are endogenous small non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. The miRNA-29 family consists of miR-29a, miR-29b, and miR-29c, among which miR-29b is the most highly expressed and is found at two genomic loci. Recently, numerous studies have demonstrated that aberrant expression of miR-29b is common in the majority of human cancers. miR-29b is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain conditions. In this review, we illustrate the role of miR-29b in cancer regulation, function, and signaling. This is the first review highlighting the role of miR-29b in cancer. Our review aims to summarize the effects of miR-29b on cancer activity and its interactions with target genes and signaling pathways, as well as to provide therapeutic implications for overcoming cancer chemoresistance.

KEYWORDS:

biological function; cancer; chemoresistance; miR-29b; oncogene; tumor promoter

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