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Indian J Dent. 2015 Jan-Mar;6(1):20-6. doi: 10.4103/0975-962X.151697.

Comparison of Periochip (chlorhexidine gluconate 2.5 mg) and Arestin (Minocycline hydrochloride 1 mg) in the management of chronic periodontitis.

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Department of Dentistry, Chintpurni Medical College and Hospital, Bungal, Pathankot, India.
Department of Periodontology, Gian Sagar Dental College and Hospital, Patiala, India.



The aim of the study was to compare the efficacy of chlorhexidine gluconate 2.5 mg (Periochip) and Minocycline hydrochloride 1 mg (Arestin) as local drug delivery agents in the management of chronic periodontitis.


Twenty patients in the age group of 30-50 years suffering from chronic periodontitis (12 males and 8 females), with almost identical probing depth bilaterally (5-8 mm), and exhibiting bleeding on probing were selected and divided into two groups: Group I consisted of periodontal pockets on the left side and received Periochip and group II consisted of periodontal pockets on the right side and received Arestin. Patients were recalled after 6 weeks and 3 months intervals from the baseline visit to record plaque index, gingival index, and probing depth.


There was reduction in all the parameters in both the groups at 6 weeks and 3 months as compared to baseline.


From the results of the present study, it was concluded that both the drugs were equally effective in reduction of plaque scores as well as gingival scores. It was further observed that Arestin resulted in better results at 6 weeks while Periochip showed better results at 3 months with respect to probing depth reduction.


Antimicrobial agents; Minocycline microspheres (Arestin); chlorhexidine gluconate (Periochip); chronic periodontitis; local drug delivery agents

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