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Trends Endocrinol Metab. 2015 Apr;26(4):185-92. doi: 10.1016/j.tem.2015.02.003. Epub 2015 Mar 9.

Emerging roles of GPER in diabetes and atherosclerosis.

Author information

1
Molecular Internal Medicine, University of Zurich, Switzerland. Electronic address: barton@access.uzh.ch.
2
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87120, USA; UNM Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87120, USA. Electronic address: eprossnitz@salud.unm.edu.

Abstract

The G protein-coupled estrogen receptor (GPER) is a 7-transmembrane receptor implicated in rapid estrogen signaling. Originally cloned from vascular endothelial cells, GPER plays a central role in the regulation of vascular tone and cell growth as well as lipid and glucose homeostasis. This review highlights our knowledge of the physiological and pathophysiological functions of GPER in the pancreas, peripheral and immune tissues, and the arterial vasculature. Recent findings on its roles in obesity, diabetes, and atherosclerosis, including GPER-dependent regulation of lipid metabolism and inflammation, are presented. The therapeutic potential of targeting GPER-dependent pathways in chronic diseases such as coronary artery disease and diabetes and in the context of menopause is also discussed.

KEYWORDS:

GPER; atherosclerosis; diabetes; estrogen receptor; rapid signaling

PMID:
25767029
PMCID:
PMC4731095
DOI:
10.1016/j.tem.2015.02.003
[Indexed for MEDLINE]
Free PMC Article

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