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Exp Mol Med. 2015 Mar 13;47:e150. doi: 10.1038/emm.2014.122.

The role of mitochondrial DNA mutation on neurodegenerative diseases.

Author information

1
Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.

Abstract

Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.

PMID:
25766619
PMCID:
PMC4351410
DOI:
10.1038/emm.2014.122
[Indexed for MEDLINE]
Free PMC Article

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