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Trends Neurosci. 2015 Apr;38(4):226-36. doi: 10.1016/j.tins.2015.02.003. Epub 2015 Mar 9.

RNA-binding proteins in neurodegeneration: Seq and you shall receive.

Author information

1
Department of Cellular and Molecule Medicine, Institute for Genomic Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA, USA.
2
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA. Electronic address: clagiert@ucsd.edu.
3
Department of Cellular and Molecule Medicine, Institute for Genomic Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA, USA; Department of Physiology, National University of Singapore, Singapore. Electronic address: geneyeo@ucsd.edu.

Abstract

As critical players in gene regulation, RNA binding proteins (RBPs) are taking center stage in our understanding of cellular function and disease. In our era of bench-top sequencers and unprecedented computational power, biological questions can be addressed in a systematic, genome-wide manner. Development of high-throughput sequencing (Seq) methodologies provides unparalleled potential to discover new mechanisms of disease-associated perturbations of RNA homeostasis. Complementary to candidate single-gene studies, these innovative technologies may elicit the discovery of unexpected mechanisms, and enable us to determine the widespread influence of the multifunctional RBPs on their targets. Given that the disruption of RNA processing is increasingly implicated in neurological diseases, these approaches will continue to provide insights into the roles of RBPs in disease pathogenesis.

KEYWORDS:

RNA binding protein; high-throughput sequencing; neurodegeneration; polyadenylation; splicing

PMID:
25765321
PMCID:
PMC4403644
DOI:
10.1016/j.tins.2015.02.003
[Indexed for MEDLINE]
Free PMC Article

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