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Acta Histochem. 2015 May-Jun;117(4-5):339-54. doi: 10.1016/j.acthis.2015.02.007. Epub 2015 Mar 9.

MicroRNA and pediatric tumors: Future perspectives.

Author information

1
IOM Ricerca s.r.l., Via Penninazzo 11, 95029 Viagrande, Italy. Electronic address: sarogulino@hotmail.com.
2
IOM Ricerca s.r.l., Via Penninazzo 11, 95029 Viagrande, Italy.
3
Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 64, 95127 Catania, Italy.

Abstract

A better understanding of pediatric tumor biology is needed to allow the development of less toxic and more efficient therapies, as well as to provide novel reliable biomarkers for diagnosis and risk stratification. The emerging role of microRNAs in controlling key pathways implicated in tumorigenesis makes their use in diagnostics a powerful novel tool for the early detection, risk assessment and prognosis, as well as for the development of innovative anticancer therapies. This perspective would be more urgent for the clinical management of pediatric cancer. In this review, we focus on the involvement of microRNAs in the biology of the main childhood tumors, describe their clinical significance and discuss their potential use as novel therapeutic tools and targets.

KEYWORDS:

Circulating biomarker; MicroRNA; Pediatric cancer

PMID:
25765112
DOI:
10.1016/j.acthis.2015.02.007
[Indexed for MEDLINE]

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