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J Infect Dis. 2015 Apr 1;211 Suppl 2:S50-7. doi: 10.1093/infdis/jiu816.

Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.

Author information

1
Knowledge Synthesis Inc., Berkeley, California.
2
IRCCS San Raffaele Scientific Institute, Milan, Italy.
3
HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of, Military Medicine, Inc., NIH, DHHS, Bethesda, Maryland.
4
Center for Disease Control and Prevention, Atlanta, Georgia.
5
Forschungszentrum Borstel, Germany.
6
Rutgers University, New Jersey.
7
Critical Path Institute, Tucson, Arizona.
8
FIND, Geneva, Switzerland.

Abstract

Tuberculosis remains a major global public health challenge. Although incidence is decreasing, the proportion of drug-resistant cases is increasing. Technical and operational complexities prevent Mycobacterium tuberculosis drug susceptibility phenotyping in the vast majority of new and retreatment cases. The advent of molecular technologies provides an opportunity to obtain results rapidly as compared to phenotypic culture. However, correlations between genetic mutations and resistance to multiple drugs have not been systematically evaluated. Molecular testing of M. tuberculosis sampled from a typical patient continues to provide a partial picture of drug resistance. A database of phenotypic and genotypic testing results, especially where prospectively collected, could document statistically significant associations and may reveal new, predictive molecular patterns. We examine the feasibility of integrating existing molecular and phenotypic drug susceptibility data to identify associations observed across multiple studies and demonstrate potential for well-integrated M. tuberculosis mutation data to reveal actionable findings.

KEYWORDS:

database; drug resistance; drug susceptibility testing; genomic sequencing; resistance-associated mutations; tuberculosis

PMID:
25765106
PMCID:
PMC4366577
DOI:
10.1093/infdis/jiu816
[Indexed for MEDLINE]
Free PMC Article

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