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PLoS Pathog. 2015 Mar 12;11(3):e1004651. doi: 10.1371/journal.ppat.1004651. eCollection 2015 Mar.

Neutrophils: Between host defence, immune modulation, and tissue injury.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
2
Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.
3
Institute of Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.
4
Department of Pediatrics I, University of Tübingen, Tübingen, Germany.
5
3rd Dept. of Medicine, Johannes Gutenberg-University Medical Center, Mainz, Germany.
6
Department of Pediatric Pneumology and Immunology, Charité Hospital, Humboldt University, Berlin, Germany; Fachbereich Immunologie, Labor Berlin Charité Vivantes GmbH, Berlin, Germany.
7
Theodor Kocher Institute, University of Bern, Bern, Switzerland.
8
Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
9
Department of Internal Medicine II, University of Tübingen, Tübingen, Germany.

Abstract

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

PMID:
25764063
PMCID:
PMC4357453
DOI:
10.1371/journal.ppat.1004651
[Indexed for MEDLINE]
Free PMC Article

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