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J Infect Dis. 2015 Oct 1;212(7):1093-9. doi: 10.1093/infdis/jiv158. Epub 2015 Mar 11.

Antibody Response is More Likely to Pneumococcal Proteins Than to Polysaccharide After HIV-associated Invasive Pneumococcal Disease.

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Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark.
Immunobiology Unit, Institute of Child Health, University College London, United Kingdom.
Department of Infectious Diseases Clinical Research Centre, Hvidovre Hospital Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.



Human immunodeficiency virus (HIV)-infected individuals are at increased risk of invasive pneumococcal disease (IPD). In order to assess the immunogenicity of pneumococcal proteins and polysaccharide, we investigated protein and serotype-specific antibody responses after HIV-associated IPD.


Specific antipneumococcal immunoglobulin G to 27 pneumococcal protein antigens and 30 serotype polysaccharides was measured in plasma before and after IPD in HIV-infected individuals and compared to HIV-infected individuals without IPD.


Over time, 81% of IPD cases responded to at least 1 protein compared to 51% of non-IPD controls. HIV IPD cases responded to more proteins than non-IPD controls (8.6 ± 8.4 vs 4.2 ± 7.6 proteins; P = .01), and had a significantly higher probability of yielding an antibody response to the proteins PiaA, PsaA, and PcpA. Twenty-two percent of HIV-infected individuals with IPD had a serotype-specific antibody response. Younger age at the time of IPD was the only predictor of a serotype-specific pneumococcal antibody response, whereas we did not identify predictors of a protein-specific antibody response.


Antibody responses occurred more frequently to pneumococcal proteins than to polysaccharide, and protein antibodies persisted for longer than polysaccharide-specific antibodies. PcpA, PiaA, and PsaA were the most immunogenic proteins.


HAART; HIV; IPD; Streptococcus pneumoniae; antibody; pneumococcal vaccines; pneumococcus

[Indexed for MEDLINE]

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