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J Infect Dis. 2015 Oct 1;212(7):1093-9. doi: 10.1093/infdis/jiv158. Epub 2015 Mar 11.

Antibody Response is More Likely to Pneumococcal Proteins Than to Polysaccharide After HIV-associated Invasive Pneumococcal Disease.

Author information

1
Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark.
2
Immunobiology Unit, Institute of Child Health, University College London, United Kingdom.
3
Department of Infectious Diseases Clinical Research Centre, Hvidovre Hospital Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Abstract

BACKGROUND:

Human immunodeficiency virus (HIV)-infected individuals are at increased risk of invasive pneumococcal disease (IPD). In order to assess the immunogenicity of pneumococcal proteins and polysaccharide, we investigated protein and serotype-specific antibody responses after HIV-associated IPD.

METHODS:

Specific antipneumococcal immunoglobulin G to 27 pneumococcal protein antigens and 30 serotype polysaccharides was measured in plasma before and after IPD in HIV-infected individuals and compared to HIV-infected individuals without IPD.

RESULTS:

Over time, 81% of IPD cases responded to at least 1 protein compared to 51% of non-IPD controls. HIV IPD cases responded to more proteins than non-IPD controls (8.6 ± 8.4 vs 4.2 ± 7.6 proteins; P = .01), and had a significantly higher probability of yielding an antibody response to the proteins PiaA, PsaA, and PcpA. Twenty-two percent of HIV-infected individuals with IPD had a serotype-specific antibody response. Younger age at the time of IPD was the only predictor of a serotype-specific pneumococcal antibody response, whereas we did not identify predictors of a protein-specific antibody response.

CONCLUSIONS:

Antibody responses occurred more frequently to pneumococcal proteins than to polysaccharide, and protein antibodies persisted for longer than polysaccharide-specific antibodies. PcpA, PiaA, and PsaA were the most immunogenic proteins.

KEYWORDS:

HAART; HIV; IPD; Streptococcus pneumoniae; antibody; pneumococcal vaccines; pneumococcus

PMID:
25762789
DOI:
10.1093/infdis/jiv158
[Indexed for MEDLINE]

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