Format

Send to

Choose Destination
J Virol. 2015 May;89(10):5204-12. doi: 10.1128/JVI.03684-14. Epub 2015 Mar 11.

The Road Less Traveled: HIV's Use of Alternative Routes through Cellular Pathways.

Author information

1
Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel.
2
Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel alian@tx.technion.ac.il.

Abstract

Pathogens such as HIV-1, with their minimalist genomes, must navigate cellular networks and rely on hijacking and manipulating the host machinery for successful replication. Limited overlap of host factors identified as vital for pathogen replication may be explained by considering that pathogens target, rather than specific cellular factors, crucial cellular pathways by targeting different, functionally equivalent, protein-protein interactions within that pathway. The ability to utilize alternative routes through cellular pathways may be essential for pathogen survival when restricted and provide flexibility depending on the viral replication stage and the environment in the infected host. In this minireview, we evaluate evidence supporting this notion, discuss specific HIV-1 examples, and consider the molecular mechanisms which allow pathogens to flexibly exploit different routes.

PMID:
25762730
PMCID:
PMC4442546
DOI:
10.1128/JVI.03684-14
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center