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Bioinformatics. 2015 Jul 15;31(14):2403-5. doi: 10.1093/bioinformatics/btv140. Epub 2015 Mar 10.

miR2GO: comparative functional analysis for microRNAs.

Author information

1
Department of Microbiology, Immunology and Biochemistry and Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Abstract

miR2GO is a web-based platform for comparative analyses of human miRNA functions. It includes two programs: miRmut2GO and miRpair2GO. miRmut2GO implements a knowledge-based method to assess the functional effects of genetic and somatic mutations in microRNA seed regions. The functional effects of a mutation are analysed by semantic comparison of enriched gene ontology (GO) annotations of the target gene sets for the wild-type and mutated alleles. miRpair2GO compares the functions of two different miRNAs based on the enriched functional annotations of their target gene sets.

AVAILABILITY AND IMPLEMENTATION:

The miR2GO web server is available at http://compbio.uthsc.edu/miR2GO.

PMID:
25762653
DOI:
10.1093/bioinformatics/btv140
[Indexed for MEDLINE]

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