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J Child Neurol. 2015 Oct;30(11):1507-14. doi: 10.1177/0883073815572686. Epub 2015 Mar 11.

Resting State and Diffusion Neuroimaging Predictors of Clinical Improvements Following Constraint-Induced Movement Therapy in Children With Hemiplegic Cerebral Palsy.

Author information

1
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
2
Holland Bloorview Kids Rehabilitation Hospital, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
3
CanChild Centre for Childhood Disability Research, McMaster University and McMaster Children's Hospital, Hamilton, Ontario, Canada.
4
Department of Paediatrics, University of Western Ontario, London, Ontario, Canada.
5
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada Centre for Functional and Metabolic Mapping, the University of Western Ontario, London, Ontario, Canada rmenon@robarts.ca.

Abstract

The aim was to identify neuroimaging predictors of clinical improvements following constraint-induced movement therapy. Resting state functional magnetic resonance and diffusion tensor imaging data was acquired in 7 children with hemiplegic cerebral palsy. Clinical and magnetic resonance imaging (MRI) data were acquired at baseline and 1 month later following a 3-week constraint therapy regimen. A more negative baseline laterality index characterizing an atypical unilateral sensorimotor resting state network significantly correlated with an improvement in the Canadian Occupational Performance Measure score (r = -0.81, P = .03). A more unilateral network with decreased activity in the affected hemisphere was associated with greater improvements in clinical scores. Higher mean diffusivity in the posterior limb of the internal capsule of the affect tract correlated significantly with improvements in the Jebsen-Taylor score (r = -0.83, P = .02). Children with more compromised networks and tracts improved the most following constraint therapy.

KEYWORDS:

cerebral palsy; constraint-induced movement therapy; functional magnetic resonance imaging; resting state

PMID:
25762587
DOI:
10.1177/0883073815572686
[Indexed for MEDLINE]

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