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Cardiovasc Intervent Radiol. 2015 Oct;38(5):1335-8. doi: 10.1007/s00270-015-1056-9. Epub 2015 Mar 12.

Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome.

Author information

1
Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. ashasarma@gmail.com.
2
Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. pshyn@partners.org.
3
Department of Radiology, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, R3T 2N2, Canada.
4
Department of Anesthesiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
5
Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
6
Department of Medicine, Dana Farber Cancer Institute, 44 Binney St., Boston, MA, 02115, USA.
7
Department of Endocrinology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA.

Abstract

Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: O ne was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.

KEYWORDS:

Adrenal hyperplasia; Cushing’s syndrome; Ectopic ACTH syndrome; Image-guided intervention; Microwave ablation

PMID:
25762486
DOI:
10.1007/s00270-015-1056-9
[Indexed for MEDLINE]

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