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Clin Infect Dis. 2015 Jun 15;60(12):1829-36. doi: 10.1093/cid/civ197. Epub 2015 Mar 11.

Hepatitis C virus therapeutic development: in pursuit of "perfectovir".

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Kirby Institute, University of New South Wales St Vincent's Hospital, Sydney, Australia.
Toronto Centre for Liver Disease, Sandra Rotman Centre for Global Health, University of Toronto, Ontario, Canada.


The next decade will be a crucial period in the public health response to hepatitis C virus (HCV) infection. The rapid development of direct-acting antiviral (DAA) therapy for HCV infection has brought considerable optimism to the HCV sector, with the realistic hope that therapeutic intervention will soon provide near-optimal efficacy with well-tolerated short-duration, all-oral regimens. As the zenith in HCV therapeutic development approaches, there remain several key obstacles to the broad implementation of interferon-free DAA regimens. The extent of HCV screening and disease assessment, global and national public health prioritization, and drug pricing will determine the potential impact on disease burden derived from introduction of these exciting new HCV therapies. Public health partnerships and advocacy will be crucial to remove barriers to enhanced HCV treatment access.


directly acting antivirals; global access; hepatitis C

[Indexed for MEDLINE]

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