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Mol Biol Evol. 1989 May;6(3):290-300.

Variances of the average numbers of nucleotide substitutions within and between populations.

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Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77225.


Statistical methods for computing the variances of nucleotide diversity within populations and of nucleotide divergence between populations are developed. Both variances are computed by finding the phylogenetic relationships of the DNA sequences studied through the unweighted pair-group method or some other tree-making method. The methods developed are applicable to both DNA sequence and restriction-site map data.

[Indexed for MEDLINE]

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