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J Immunol Res. 2014;2014:380405. doi: 10.1155/2014/380405. Epub 2014 Nov 5.

Expression of TNF-α, APRIL and BCMA in Behcet's disease.

Author information

1
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Egypt.
2
Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt.
3
Department of Internal Medicine, Kasr Al-Aini Hospital, Faculty of Medicine, Cairo University, Giza, Egypt.

Abstract

BACKGROUND:

Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet's disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells.

OBJECTIVE:

Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD.

PATIENTS AND METHODS:

This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques.

RESULTS:

The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner (P < 0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet's disease current activity forum) index (r 0.68, P < 0.001). None of the TNF family members tested was affected by a positive pathergy test.

CONCLUSIONS:

Patients have significantly higher levels of TNF family members' (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.

PMID:
25759827
PMCID:
PMC4236893
DOI:
10.1155/2014/380405
[Indexed for MEDLINE]
Free PMC Article

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