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Trends Immunol. 2015 Apr;36(4):250-6. doi: 10.1016/j.it.2015.02.003. Epub 2015 Mar 7.

The STING pathway and the T cell-inflamed tumor microenvironment.

Author information

1
Department of Pathology, The University of Chicago, Chicago, IL, USA.
2
Department of Pathology, The University of Chicago, Chicago, IL, USA; Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, USA. Electronic address: tgajewsk@medicine.bsd.uchicago.edu.

Abstract

A major subset of patients with advanced solid tumors show a spontaneous T cell-inflamed tumor microenvironment, which has prognostic import and is associated with clinical response to immunotherapies. As such, understanding the mechanisms governing the generation of spontaneous T cell responses in only a subset of patients is critical for advancing immunotherapeutic approaches further. Here, we discuss the characteristics of T cell-inflamed versus non-inflamed tumors, including a type I interferon (IFN) signature associated with T cell priming against tumor antigens. We review recent findings that have pointed towards the STING (stimulator of interferon genes) pathway of cytosolic DNA sensing as an important innate immune sensing mechanism driving type I IFN production in the tumor context. Knowledge of this pathway is guiding the further development of novel immunotherapeutic strategies.

PMID:
25758021
PMCID:
PMC4393801
DOI:
10.1016/j.it.2015.02.003
[Indexed for MEDLINE]
Free PMC Article

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