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J Cereb Blood Flow Metab. 2015 May;35(5):747-50. doi: 10.1038/jcbfm.2015.32. Epub 2015 Mar 11.

Striatal blood-brain barrier permeability in Parkinson's disease.

Author information

1
1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
2
1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada [3] Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.

Abstract

In vivo studies have shown that blood-brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.

PMID:
25757748
PMCID:
PMC4420870
DOI:
10.1038/jcbfm.2015.32
[Indexed for MEDLINE]
Free PMC Article

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