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Nat Rev Neurosci. 2015 Apr;16(4):226-33. doi: 10.1038/nrn3878. Epub 2015 Mar 11.

Disentangling calcium-driven astrocyte physiology.

Author information

1
UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

Abstract

Astrocytes seem to rely on relatively sluggish and spatially blurred Ca(2+) waves to communicate with fast and point-precise neural circuits. This apparent discrepancy could, however, reflect our current inability to understand the microscopic mechanisms involved. Difficulties in detecting and interpreting astrocyte Ca(2+) signals may have led to some prominent controversies in the field. Here, we argue that a deeper understanding of astrocyte physiology requires a qualitative leap in our experimental and analytical strategies.

PMID:
25757560
DOI:
10.1038/nrn3878
[Indexed for MEDLINE]

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