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PLoS Negl Trop Dis. 2015 Mar 10;9(3):e0003463. doi: 10.1371/journal.pntd.0003463. eCollection 2015 Mar.

Impact of helminth infection during pregnancy on cognitive and motor functions of one-year-old children.

Author information

1
Université Pierre et Marie Curie (UPMC- Paris VI), Paris, France; Ecole des Hautes Etudes en Santé Publique, Département d'Épidémiologie et des Biostatistiques, Rennes, France; Institut de Recherche pour le Développement (IRD), Mère et Enfant face aux Infections Tropicales, Paris, France.
2
Michigan State University, Departments of Psychiatry and Neurology/Ophthalmology, East Lansing, Michigan, United States of America.
3
Columbia University, Mailman School of Public Health and the College of Physicians and Surgeons, New York, New York, United States of America.
4
Institut de Recherche pour le Développement (IRD), Mère et Enfant face aux Infections Tropicales, Paris, France; Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso.
5
Union Internationale Contre la Tuberculose et les Maladies Respiratoires, Département Tuberculose et VIH, Paris, France.
6
Hôpital de la Mère et de l'Enfant Lagune de Cotonou, Service de Pédiatrie, Cotonou, Bénin.
7
Université d'Abomey-Calavi, Faculté des Sciences de la Santé, Cotonou, Bénin.
8
Institut de Recherche pour le Développement (IRD), Mère et Enfant face aux Infections Tropicales, Paris, France; PRES Sorbonne Paris Cité, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
9
Ecole des Hautes Etudes en Santé Publique, Département d'Épidémiologie et des Biostatistiques, Rennes, France; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France; New York University Medical Center, Division of Parasitology, Department of Microbiology, New York, New York, United States of America.

Abstract

OBJECTIVE:

To determine the effect of helminth infection during pregnancy on the cognitive and motor functions of one-year-old children.

METHODS:

Six hundred and thirty five singletons born to pregnant women enrolled before 29 weeks of gestation in a trial comparing two intermittent preventive treatments for malaria were assessed for cognitive and motor functions using the Mullen Scales of Early Learning, in the TOVI study, at twelve months of age in the district of Allada in Benin. Stool samples of pregnant women were collected at recruitment, second antenatal care (ANC) visit (at least one month after recruitment) and just before delivery, and were tested for helminths using the Kato-Katz technique. All pregnant women were administered a total of 600 mg of mebendazole (100 mg two times daily for 3 days) to be taken after the first ANC visit. The intake was not directly observed.

RESULTS:

Prevalence of helminth infection was 11.5%, 7.5% and 3.0% at first ANC visit, second ANC visit and at delivery, respectively. Children of mothers who were infected with hookworms at the first ANC visit had 4.9 (95% CI: 1.3-8.6) lower mean gross motor scores compared to those whose mothers were not infected with hookworms at the first ANC visit, in the adjusted model. Helminth infection at least once during pregnancy was associated with infant cognitive and gross motor functions after adjusting for maternal education, gravidity, child sex, family possessions, and quality of the home stimulation.

CONCLUSION:

Helminth infection during pregnancy is associated with poor cognitive and gross motor outcomes in infants. Measures to prevent helminth infection during pregnancy should be reinforced.

PMID:
25756357
PMCID:
PMC4355614
DOI:
10.1371/journal.pntd.0003463
[Indexed for MEDLINE]
Free PMC Article

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