PLoS One. 2015 Mar 10;10(3):e0119851. doi: 10.1371/journal.pone.0119851. eCollection 2015.

DivStat: a user-friendly tool for single nucleotide polymorphism analysis of genomic diversity.

Soares I¹, Moleirinho A², Oliveira GN³, Amorim A².

Author information

1: IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias s/n, 4200-465, Porto, Portugal.
2: IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias s/n, 4200-465, Porto, Portugal; Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.
3: Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal; IFIMUP and IN-Institute of Nanoscience and Nanotechnology, Rua do Campo Alegre, 687, 4169-007, Porto, Portugal.

Abstract

Recent developments have led to an enormous increase of publicly available large genomic data, including complete genomes. The 1000 Genomes Project was a major contributor, releasing the results of sequencing a large number of individual genomes, and allowing for a myriad of large scale studies on human genetic variation. However, the tools currently available are insufficient when the goal concerns some analyses of data sets encompassing more than hundreds of base pairs and when considering haplotype sequences of single nucleotide polymorphisms (SNPs). Here, we present a new and potent tool to deal with large data sets allowing the computation of a variety of summary statistics of population genetic data, increasing the speed of data analysis.