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J Infect Dis. 2015 Sep 15;212(6):914-23. doi: 10.1093/infdis/jiv139. Epub 2015 Mar 9.

CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus.

Author information

1
Division of Infectious Diseases, Department of Medicine.
2
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
3
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore.
4
Division of Infectious Diseases, Department of Medicine Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore.
5
Division of Infectious Diseases, Department of Medicine Department of Oncology, Johns Hopkins University School of Medicine.

Abstract

BACKGROUND:

Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role.

METHODS:

To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection.

RESULTS:

A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4(+) T-cell counts <350/mm(3) after HIV infection, and subjects with CD4(+) T-cell counts <200/mm(3) also showed a reduction in nAb breadth. Subjects who maintained CD4(+) T-cell counts ≥350/mm(3) displayed little to no decline in antibody levels.

CONCLUSIONS:

Depletion of CD4(+) T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.

KEYWORDS:

HCV; HIV; coinfection; neutralizing antibody

PMID:
25754978
PMCID:
PMC4548462
DOI:
10.1093/infdis/jiv139
[Indexed for MEDLINE]
Free PMC Article

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