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AIDS Res Hum Retroviruses. 1989 Dec;5(6):613-20.

Downregulation of HLA class I antigens in HIV-1-infected cells.

Author information

1
Institut für Virologie und Immunobiologie der Universität, Würzburg, FRG.

Abstract

By means of indirect immunofluorescence analysis we investigated the effect of HIV-1 infection on HLA class I surface antigens. We report here that in CD4+ HeLa cells, in H9 cells, and in peripheral T lymphocytes HLA class I antigens are downregulated following infection with HIV-1. The downregulation is effected at a posttranscriptional level since the amounts of HLA class I specific mRNA are similar in infected and uninfected cells. This phenomenon is not only correlated with the state of infection, that is, the presence of P24 of HIV-1 in the cells, but also depends on the time of infection. Upon HLA class I downregulation by HIV infection, the specific lysis of peripheral blood cells by allogeneic CTL is reduced.

PMID:
2575399
DOI:
10.1089/aid.1989.5.613
[Indexed for MEDLINE]

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