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Clin Transl Sci. 2015 Aug;8(4):388-90. doi: 10.1111/cts.12264. Epub 2015 Mar 9.

Case Study: Community Engagement and Clinical Trial Success: Outreach to African American Women.

Author information

1
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
2
Department of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
3
Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine; Department of Medicine, Meharry Medical College, Nashville, Tennessee, USA.

Abstract

This brief report examines how the use of community engagement principles and approaches enhanced clinical trial recruitment and retention. The Community-Engaged Research Core (CERC), a CTSA-supported resource designed to facilitate community involvement in clinical and translational research, was consulted to provide assistance with the implementation of the clinical trial, and specifically to enhance participation of the target population-African American women. CERC's key recommendations included: (1) convene a Community Engagement Studio, (2) redesign the recruitment advertisement, (3) simplify the language used to explain the scope of the study, and (4) provide transportation for participants. As a result of these interventions, a comprehensive strategy to recruit, enroll, and retain participants was formulated. After implementation of the plan by the study team, enrollment increased 78% and recruitment goals were met 16 months ahead of schedule. Participant retention and study drug adherence was 100%. We conclude that community engagement is essential to the development of an effective multifaceted plan to improve recruitment of underrepresented groups in clinical trials.

KEYWORDS:

blood pressure; cholesterol; diabetes; hypertension; insulin; nitric oxide

PMID:
25752995
PMCID:
PMC4553110
DOI:
10.1111/cts.12264
[Indexed for MEDLINE]
Free PMC Article

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