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Arch Microbiol. 2015 Jun;197(5):657-64. doi: 10.1007/s00203-015-1101-8. Epub 2015 Mar 10.

Vaginal Lactobacillus gasseri CMUL57 can inhibit herpes simplex type 2 but not Coxsackievirus B4E2.

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Université de Lille 1 Sciences et Technologies, Laboratoire Régional de Recherche en Agroalimentaire et Biotechnologies, Institut Charles Viollette-Université Lille 1, Bâtiment Polytech-Lille, Bâtiment Polytech-Lille (Bureau C315), Cité Scientifique, Université de Lille, Avenue Paul Langevin, 59655, Villeneuve d'Ascq Cedex, France.


This study aimed at demonstrating the antiviral activity of Lactobacillus gasseri CMUL57 (L. gasseri CMUL57), L. acidophilus CMUL67 and L. plantarum CMUL140 against herpes simplex type 2 (HSV-2) and Coxsackievirus B4E2 (CVB4E2), which are enveloped and naked viruses, respectively. These lactobacilli were non-cytotoxic and were able to reduce the cytopathic effect induced by HSV-2 in Vero cell monolayers. However, lactobacilli were not active against CVB4E2. Tested lactobacilli displayed anti-HSV-2 activity when they were co-incubated with the virus prior to inoculating the mixture to Vero cell monolayers. The detection of HSV-2 DNA by PCR in pellets of bacteria/virus mixtures let us to hypothesize that anti-HSV-2 activity of lactobacilli resulted from the viruses' entrapment. This study showed the capabilities of vaginal lactobacilli to inhibit enveloped viruses such as HSV-2.

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