Format

Send to

Choose Destination
Appl Radiat Isot. 2015 May;99:133-7. doi: 10.1016/j.apradiso.2015.02.024. Epub 2015 Feb 27.

Automated radiosynthesis of [(18)F]ciprofloxacin.

Author information

1
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
2
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
3
Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
4
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria. Electronic address: oliver.langer@ait.ac.at.

Abstract

We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [(18)F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% (n=23) with a specific activity at EOS of 1.4±0.5GBq/µmol in a synthesis time of 160min.

KEYWORDS:

(18)F/(19)F exchange; Automated synthesis; Radiochemical yield; Reactor type; TRACERlab(TM) FX(FDG); [(18)F]ciprofloxacin

PMID:
25752570
DOI:
10.1016/j.apradiso.2015.02.024
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center