Abstract
The development of an efficient and robust process for the production of HIV NNRTI doravirine is described. The synthesis features a continuous aldol reaction as part of a de novo synthesis of the key pyridone fragment. Conditions for the continuous flow aldol reaction were derived using microbatch snapshots of the flow process.
MeSH terms
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Aldehydes / chemistry
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HIV Infections / drug therapy*
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HIV Reverse Transcriptase / antagonists & inhibitors*
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Molecular Structure
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Pyridones / chemical synthesis*
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Pyridones / chemistry
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Pyridones / pharmacology
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Reverse Transcriptase Inhibitors / chemical synthesis*
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology
Substances
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Aldehydes
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Pyridones
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Reverse Transcriptase Inhibitors
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Triazoles
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3-hydroxybutanal
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doravirine
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HIV Reverse Transcriptase