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Nat Struct Mol Biol. 2015 Apr;22(4):345-7. doi: 10.1038/nsmb.2996. Epub 2015 Mar 9.

Structural organization of the dynein-dynactin complex bound to microtubules.

Author information

1
Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California, USA.
2
Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible.

PMID:
25751425
PMCID:
PMC4385409
DOI:
10.1038/nsmb.2996
[Indexed for MEDLINE]
Free PMC Article
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