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Anticancer Res. 2015 Mar;35(3):1743-8.

The effect of re-operation on survival in patients with recurrent glioblastoma.

Author information

1
Department of Medical Oncology, Azienda USL - IRCCS Institute of Neurological Sciences, Bologna, Italy.
2
Department of Neurosurgery, Bellaria Hospital, Azienda USL - IRCCS Institute of Neurological Sciences, Bologna, Italy.
3
Department of Health Sciences, University of L'Aquila, L'Aquila, Italy.
4
Section of Neurosurgery, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, University Hospital, Verona, Italy.
5
Department of Neuroscience and Neurosurgery, San Bortolo Hospital, Vicenza, Italy.
6
Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Section of Pathology, M. Malpighi, Bellaria Hospital, Bologna, Italy.
7
Pathology Department, San Bortolo Hospital, Vicenza, Italy.
8
Department of Neurosciences, Statistic and Informatic Unit, Azienda Ospedale-UniversitĂ , Padova, Italy.
9
Department of Medical Oncology, Azienda USL - IRCCS Institute of Neurological Sciences, Bologna, Italy alba.brandes@yahoo.it.

Abstract

BACKGROUND:

Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown.

PATIENTS AND METHODS:

A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution.

RESULTS:

Two hundred and thirty-two patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors.

CONCLUSION:

Second surgery might have a limited impact in the clinical course of recurrent GBM patients.

KEYWORDS:

Glioblastoma; radiotherapy; second surgery; surgery; temozolomide

PMID:
25750337
[Indexed for MEDLINE]

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