Format

Send to

Choose Destination
J Clin Pathol. 2015 Jun;68(6):418-26. doi: 10.1136/jclinpath-2015-202945. Epub 2015 Mar 6.

Perivascular epithelioid tumours (PEComas) of the gynaecological tract.

Author information

1
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
2
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Abstract

Perivascular epithelioid tumours (PEComas) of the gynaecological tract are rare tumours which were first recognised and diagnosed within the last 20 years. They represent a unique diagnostic challenge with regard to their accurate and reproducible distinction from more common entities such as smooth muscle tumours of the uterine corpus. In this review article, we trace the development of the concept of the PEComa tumour family, highlight what is known about extra-gynaecological tract PEComa at an immunohistochemical, molecular and therapeutic level and then present a summary of all reported cases of gynaecological tract PEComa to date. In the summary, we highlight rare subtypes of gynaecological tract PEComa and compare the performances of extant prognostic classification systems for malignancy in these tumours.

KEYWORDS:

DIAGNOSIS; GYNAECOLOGICAL PATHOLOGY; HISTOPATHOLOGY; NEOPLASMS; UTERUS

PMID:
25750268
PMCID:
PMC4984252
DOI:
10.1136/jclinpath-2015-202945
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center