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Nat Rev Microbiol. 2015 Apr;13(4):206-16. doi: 10.1038/nrmicro3428. Epub 2015 Mar 9.

Now you see me, now you don't: the interaction of Salmonella with innate immune receptors.

Author information

1
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.

Abstract

Salmonella enterica serovars are associated with an estimated 1 million deaths annually and are also useful model organisms for investigating the mechanisms of host-bacterium interactions. The insights gained from studies on non-typhoidal Salmonella (NTS) serovars have provided a fascinating overview of the mechanisms by which the innate immune system detects and responds to bacterial pathogens. However, specific virulence factors and changes in virulence gene regulation in S. enterica subsp. enterica serovar Typhi alter the innate immune responses to this pathogen. In this Review, we compare and contrast the interactions of S. Typhi and NTS serovars with host innate immune receptors and discuss why the disease manifestations associated with S. Typhi infection differ considerably from those associated with the closely related NTS serovars.

PMID:
25749454
DOI:
10.1038/nrmicro3428
[Indexed for MEDLINE]

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