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Nat Rev Microbiol. 2015 Apr;13(4):191-205. doi: 10.1038/nrmicro3420. Epub 2015 Mar 9.

Salmonellae interactions with host processes.

Author information

1
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.
2
1] Department of Microbiology, University of Washington, Seattle, Washington 98195, USA. [2] Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA. [3] Department of Immunology, University of Washington, Seattle, Washington 98195, USA. [4] Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

Abstract

Salmonellae invasion and intracellular replication within host cells result in a range of diseases, including gastroenteritis, bacteraemia, enteric fever and focal infections. In recent years, considerable progress has been made in our understanding of the molecular mechanisms that salmonellae use to alter host cell physiology; through the delivery of effector proteins with specific activities and through the modulation of defence and stress response pathways. In this Review, we summarize our current knowledge of the complex interplay between bacterial and host factors that leads to inflammation, disease and, in most cases, control of the infection by its animal hosts, with a particular focus on Salmonella enterica subsp. enterica serovar Typhimurium. We also highlight gaps in our knowledge of the contributions of salmonellae and the host to disease pathogenesis, and we suggest future avenues for further study.

PMID:
25749450
PMCID:
PMC5074537
DOI:
10.1038/nrmicro3420
[Indexed for MEDLINE]
Free PMC Article

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