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Biochemistry (Mosc). 2014 Dec;79(13):1635-52. doi: 10.1134/S0006297914130124.

Human herpes simplex virus: life cycle and development of inhibitors.

Author information

1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. kukhan86@hotmail.com.

Abstract

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.

PMID:
25749169
DOI:
10.1134/S0006297914130124
[Indexed for MEDLINE]
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