Format

Send to

Choose Destination
Neurosci Lett. 2015 Apr 10;592:54-8. doi: 10.1016/j.neulet.2015.03.005. Epub 2015 Mar 4.

Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated.

Author information

1
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA. Electronic address: amb2139@columbia.edu.
2
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA.
3
Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
4
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
5
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
6
Department of Radiology, College of Physicians and Surgeons, Columbia University, USA.
7
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, USA.

Abstract

Emerging studies link vascular risk factors and cerebrovascular health to the prevalence and rates of progression in Alzheimer's disease (AD). The brain's ability to maintain constant blood flow across a range of cerebral perfusion pressures, or autoregulation, may both promote and result from small vessel cerebrovascular disease and AD-related amyloid pathology. Here, we examined the relationship among cerebral autoregulation, small vessel cerebrovascular disease, and amyloid deposition in 14 non-demented older adults. Reduced cerebral autoregulation, was associated with increased amyloid deposition and increased white matter hyperintensity volume, which, in turn were positively associated with each other. For the first time in humans, we demonstrate an interrelationship among AD pathology, small vessel cerebrovascular disease, and cerebral autoregulation. Vascular factors and AD pathology are not independent but rather appear to interact.

KEYWORDS:

Alzheimer; Amyloid; Cerebral autoregulation; White matter hyperintensities; ’s disease

PMID:
25748319
PMCID:
PMC4430835
DOI:
10.1016/j.neulet.2015.03.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center