Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Biochem. 2015;84:131-64. doi: 10.1146/annurev-biochem-060614-034115. Epub 2015 Feb 26.

Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.

Author information

Department of Genetics, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel; email:


Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.


chromatin; intermediate filament; laminopathies; lamins; nuclear envelope; nuclear mechanics; nuclear organization

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center