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Annu Rev Biochem. 2015;84:131-64. doi: 10.1146/annurev-biochem-060614-034115. Epub 2015 Feb 26.

Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.

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Department of Genetics, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel; email:


Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.


chromatin; intermediate filament; laminopathies; lamins; nuclear envelope; nuclear mechanics; nuclear organization

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