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Bone. 2015 Nov;80:89-94. doi: 10.1016/j.bone.2015.02.029. Epub 2015 Mar 6.

Bone muscle interactions and vitamin D.

Author information

1
Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; Garvan Institute of Medical Research, Sydney, NSW, Australia; Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, NSW, Australia; Westmead Millennium Institute, Westmead Hospital, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia. Electronic address: Jenny.gunton@sydney.edu.au.
2
Faculty of Medicine, University of Sydney, Sydney, NSW, Australia; Garvan Institute of Medical Research, Sydney, NSW, Australia; Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, NSW, Australia; Westmead Millennium Institute, Westmead Hospital, NSW, Australia.
3
Garvan Institute of Medical Research, Sydney, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
4
Department of Internal Medicine/Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands.

Abstract

Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases. This article is part of a Special Issue entitled "Muscle Bone Interactions".

KEYWORDS:

Bone; Cross-talk; Muscle; Osteoporosis; Sarcopenia; Vitamin D

PMID:
25745883
DOI:
10.1016/j.bone.2015.02.029
[Indexed for MEDLINE]

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