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Anesteziol Reanimatol. 1989 Sep-Oct;(5):3-6.

[The effect of preliminary administration of the beta-blocker inderal on the course of the postresuscitation period].

[Article in Russian]

Abstract

The results of the effect of acute fetal blood loss and a beta-blocker inderal preinjection on the functional metabolic damage of vital organs in the early postresuscitation period are presented. It has been established that the drug preinjection restricts the lipolysis and considerably decreases the intensity of lipid peroxidation in the brain, heart and liver both due to prevention of antioxidant enzyme inhibition and to preservation of antioxidant lipid activity at a high level. It has been shown that inderal, retaining phospholipid content of cardiomyocyte membranes, reduces the electrical heart instability and completely prevents ventricular fibrillation in the early postresuscitation period. Inderal decreases considerably adenyl nucleotide brain and heart catabolism.

PMID:
2574548
[Indexed for MEDLINE]

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