Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells

Eur Respir J. 2015 Jun;45(6):1745-8. doi: 10.1183/09031936.00206514. Epub 2015 Mar 5.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects*
  • Bronchi / cytology
  • Cells, Cultured
  • Chemokine CCL5 / drug effects
  • Chemokine CCL5 / genetics
  • Chemokine CXCL10 / drug effects
  • Chemokine CXCL10 / genetics
  • Epithelial Cells / drug effects*
  • Epithelial Cells / virology
  • Humans
  • In Vitro Techniques
  • Interferon-beta / drug effects
  • Interferon-beta / genetics
  • Interferons
  • Interleukins / genetics
  • Proto-Oncogene Proteins c-pim-1 / antagonists & inhibitors*
  • RNA, Messenger / drug effects*
  • RNA, Messenger / metabolism
  • RNA, Viral / analysis*
  • Rhinovirus / drug effects*
  • Viral Load / drug effects
  • Virus Replication / drug effects*

Substances

  • CCL5 protein, human
  • CXCL10 protein, human
  • Chemokine CCL5
  • Chemokine CXCL10
  • interferon-lambda, human
  • Interleukins
  • RNA, Messenger
  • RNA, Viral
  • Interferon-beta
  • Interferons
  • PIM1 protein, human
  • Proto-Oncogene Proteins c-pim-1