Format

Send to

Choose Destination
See comment in PubMed Commons below
Prog Mol Biol Transl Sci. 2015;131:409-34. doi: 10.1016/bs.pmbts.2014.11.010. Epub 2015 Jan 30.

Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain.

Author information

1
Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA. Electronic address: theodore.price@utdallas.edu.
2
Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA.

Abstract

Pain sensing neurons in the periphery (called nociceptors) and the central neurons that receive their projections show remarkable plasticity following injury. This plasticity results in amplification of pain signaling that is now understood to be crucial for the recovery and survival of organisms following injury. These same plasticity mechanisms may drive a transition to a nonadaptive chronic pain state if they fail to resolve following the termination of the healing process. Remarkable advances have been achieved in the past two decades in understanding the molecular mechanisms that underlie pain plasticity following injury. The mechanisms bear a striking resemblance to molecular mechanisms involved in learning and memory processes in other brain regions, including the hippocampus and cerebral cortex. Here those mechanisms, their commonalities and subtle differences, will be highlighted and their role in causing chronic pain will be discussed. Arising from these data is the striking argument that chronic pain is a disease of the nervous system, which distinguishes this phenomena from acute pain that is frequently a symptom alerting the organism to injury. This argument has important implications for the development of disease modifying therapeutics.

KEYWORDS:

AMPK; Atypical PKC; Axonal mRNA; BDNF; CREB; ERK; Hyperalgesic priming; IL-6; LTP; NGF; Opioid; PKMzeta; Reconsolidation; eIF4E; mTOR; trkB

PMID:
25744681
PMCID:
PMC4664460
DOI:
10.1016/bs.pmbts.2014.11.010
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center