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Prog Mol Biol Transl Sci. 2015;131:73-118. doi: 10.1016/bs.pmbts.2015.01.002. Epub 2015 Feb 12.

Sensory TRP channels: the key transducers of nociception and pain.

Author information

1
Department of Pharmacology, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
2
Department of Pharmacology, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesia, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: mohapatrad@anest.wustl.edu.

Abstract

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.

KEYWORDS:

Nociception; Pain; TRP channel; TRPA1; TRPM3; TRPM8; TRPV1; TRPV2; TRPV3; TRPV4

PMID:
25744671
PMCID:
PMC5903472
DOI:
10.1016/bs.pmbts.2015.01.002
[Indexed for MEDLINE]
Free PMC Article

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